Jeonju University South Korea
Title: Ameliorative effects of kushenol C against UV-induced skin damage in mice
Biography: Byoung Ok Cho
Sophora flavescens has traditionally been used to treat a variety of diseases such as viral hepatitis, fever, cancer, and pain. It is known to contain many bioactive compounds including prenylated flavonoids such as kurarinone, sophoraflavanone G, kuraridine and isoxanthohumol. These flavonoids have been demonstrated to have antioxidant, α-glucosidase inhibitory and anti-inflammatory properties. However, the protective activities against UV-induced skin damage of kushenol C from S. flavescens have not yet been elucidated. In the present study, we investigated the protective effect of kushenol C on UV-induced skin damage in mice. Our results showed that kushenol C treatment significantly recovered UV-induced skin damage, epidermal hyperplasia, mast cell infiltration, and collagen degradation in mice. Furthermore, kushenol C treatment significantly inhibited the production of pro-inflammatory mediators in UV-irradiated mice. More so, treatment with kushenol C inhibited oxidative stress in UV-irradiated mice. In conclusion, these results showed that kushenol C from S. flavescens has potentials as therapeutic agent against skin damage by inhibiting oxidative stress and UV-induced skin damage.