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Seon Il Jang

Seon Il Jang

Jeonju University South Korea

Title: Enzyme-treated date plum leaves extract ameliorate atopic dermatitis-like skin lesion in hairless mice


Biography: Seon Il Jang


Date plum (Diospyros lotus L.) leaf has been widely eaten for its medical importance such as sedative, antiseptics, antidiabetic and antitumor. Recently, we have demonstrated that its extract possesses the anti-obesity, anti-pruritus, protective effect of UV-induced skin damage and drug-induced liver damage.  However, no studies have been conducted to investigate the biological effect of enzyme-treated date plum leaf extract (EDLE). The present study evaluates the ameliorative effects of enzyme-treated date plum leaves extract (EDLE) in the atopic dermatitis (AD) mouse model. The results showed that administration of EDLE significantly attenuated the AD-like skin symptoms and clinical signs in 1-fluoro-2,4-dinitrobenzene (DNFB) and house dust mite (HDM) antigen-treated hairless mice. EDLE administration suppressed the serum level of immunoglobulin E (IgE), interleukin (IL)-4, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, thymic stromal lymphopoietin (TSLP), and thymus and activation-regulated chemokine (TARC) in AD mice. Furthermore, histological analyses revealed that EDLE administration suppressed the increased epidermal thickness, dermal infiltration of inflammatory cells, and infiltration and degranulation of mast cells in AD-like skin lesions. In addition, we revealed that EDLE treatment inhibited the production of IFN-γ, IL-4, and TARC in concanavalin A-stimulated splenocytes. Taken together, these results suggest that EDLE might be a candidate to treat AD.