Jeonju University South Korea
Title: Hydrolyzed celery extract ameliorate atopic dermatitis-like skin lesion in hairless mice
Biography: Jiwon Choi
Apium graveolens (celery) has been traditionally used as an herbal food and medicine. The current study investigated the ameliorative effects of acid-hydrolyzed celery leaf extract (HCE) on 1-fluoro-2,4-dinitrobenzene (DNFB) and house dust mite (HDM) antigen-induced atopic dermatitis (AD) mouse model. HCE administration decreased DNFB/HDM-induced dermatitis severity and dorsal skin thickness in hairless mice. Histological analyses demonstrated that HCE administration alleviated the epidermal thickness, dermal infiltration of inflammatory cells, and infiltration and degranulation of mast cells in AD-like skin lesions. Moreover, HCE administration attenuated serum immunoglobulin E (IgE), interleukin (IL)-4, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-6, and thymic stromal lymphopoietin (TSLP) in AD-like skin lesions in mice. Further analysis revealed that HCE treatment suppressed the production of nitric oxide, IL-6, and PGE2 in lipopolysaccharide-stimulated RAW264.7 macrophage cells. Thus, these results suggest that HCE can be considered as a therapeutic agent for the treatment of allergic skin diseases.