Day 2 :
Jeonju University South Korea
Time : 11:00 - 11:45
Byoung Ok Cho completed his Ph.D. in Pharmacology from Chosun University, Gwangju, Republic of Korea, and did his post-doctoral research in the Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Republic of Korea. Presently, he is a principal researcher, in the Research Institute, Ato Q&A Co. Ltd, Republic of Korea. His research field is centered around the therapeutic approach of atopic dermatitis: cytokines, chemokines, fillagrin, and natural products. He has more than 70 published papers in renown journals under his belt.
Sophora flavescens has traditionally been used to treat a variety of diseases such as viral hepatitis, fever, cancer, and pain. It is known to contain many bioactive compounds including prenylated flavonoids such as kurarinone, sophoraflavanone G, kuraridine and isoxanthohumol. These flavonoids have been demonstrated to have antioxidant, α-glucosidase inhibitory and anti-inflammatory properties. However, the protective activities against UV-induced skin damage of kushenol C from S. flavescens have not yet been elucidated. In the present study, we investigated the protective effect of kushenol C on UV-induced skin damage in mice. Our results showed that kushenol C treatment significantly recovered UV-induced skin damage, epidermal hyperplasia, mast cell infiltration, and collagen degradation in mice. Furthermore, kushenol C treatment significantly inhibited the production of pro-inflammatory mediators in UV-irradiated mice. More so, treatment with kushenol C inhibited oxidative stress in UV-irradiated mice. In conclusion, these results showed that kushenol C from S. flavescens has potentials as therapeutic agent against skin damage by inhibiting oxidative stress and UV-induced skin damage.