Day 2 :
Keynote Forum
Evangeline B. Handog
Chair, Department of Dermatology Asian Hospital and Medical Center Philippines
Keynote: Glutathione as a Skin Lightening Agent: Hot Issues on Safety and Efficacy
Time : 09:00 AM
Biography:
Dr. Evangeline B. Handog, FPDS, the first woman president of the International Society of Dermatology, is the chair of the Department of Dermatology of Asian Hospital and Medical Center in Alabang, Muntinlupa City. She is a volunteer consultant at the Research Institute for Tropical Medicine where she heads the Cosmetic Dermatology unit. Her interest in pigmentary conditions, particularly melasma and vitiligo is evident in her researches and recently launched book, Melasma and Vitiligo in Brown Skin (Springer). Her passion to teach young residents and help them obtain more knowledge with international mentors was clear as she is the founding chair of the Mentorship Program of the International Society of Dermatology.
Abstract:
Nowadays, skin lightening merchandise is obtainable in the form of creams, pills, soaps or lotions. Sad to note that most are experience based and not evidence based.
Mechanisms to achieve skin lightening include tyrosinase, peroxide inhibition, scavenging of reactive oxygen species and the use of agents against melanogenic inflammatory response. However, the mainstay of skin lightening is of course the regular use of sunscreens.
Glutathione is an ubiquitous compound containing a biologically active sulfhydryl (SH) group found in our bodies. Fruits and vegetables are good dietary sources of glutathione.
Glutathione as a master antioxidant, helps promote skin whitening. Acting as a primary anti-aging factor, it promotes a longer and healthier life, protects us from harmful free radical damage, supports the immune function, acts as a gate keeper for lungs and gut, detoxifies the body of noxious chemicals, helps to protect against alcohol, tobacco damage and abuse. It can regenerate spent vitamins C & E in the body.
Until recently, the mechanism of action of Glutathione as a skin whitening agent was unknown.
- direct inactivation of the enzyme tyrosinase by binding with the copper-containing active site of the enzyme
- mediating the switch mechanism from eumelanin to phaeomelanin production
- quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin Formation
- modulation of depigmenting abilities of melanocytotoxic agents. These concepts supported by the various experimental evidence presented form basis for future research in the use of glutathione in the treatment of pigmentary disorders.
Hot issues on IV Glutathione, push or drip, topical route will be dispelled.
Handog EB, Datuin MSL, Singzon IA, did an open-label, single-arm trial of 30 Filipino females (Fitzpatrick skin types IV or V) receiving a glutathione-containing lozenge daily for eight weeks. The authors found a signiï¬cant decrease in melanin indices from baseline to end point. No serious adverse events, and laboratory examination ï¬ndings remained normal.
Session Introduction
Firas Al-Niaimi
152 Harley street, London, UK
Title: Non-cosmetic off-license uses of botulinum toxin in clinical dermatology
Biography:
Dr Firas Al-Niaimi is a highly experienced consultant dermatologist with over 15 years’ experience and an international standing and trained in some of the UK's top hospitals. Hes has a passion for education, research and science & has over 150 publications in Dermatology and lasers (including on filler complications) making him one of the most prolific and well-published consultant dermatologists in the UK. In addition to this he has more than 200 scientific presentations all around the world where he is regularly invited to speak in addition to several chapters of books and his own book.
Abstract:
Botulinum neurotoxin (BoNT) is renowned for its inhibitory effects on the neuromuscular junction and is widely used in cosmetic dermatology. The evidence for its use in cosmetic dermatology and in non-dermatological indications is well established and more and more applications of its use beyond cosmetics are being discovered. In this presentation the currect evidence for the non-cosmetic dermatological uses of BoNT will be presented as well as my own personal; experience. The use is ion a multitude of dermatological diseases, including (but not limited to) hyperhidrosis, Darier’s disease, Hailey-Hailey disease, pompholyx, scarring, rosacea and hidradenitis suppurativa. Tips regarding the method of use and combination treatments will be discussed.
Mustafa Turhan Sahin
Celal Bayar University,Turkey
Title: Trichoscopy in Alopecias: A Valuable and Noninvasive Technique
Biography:
He completed medical education in Erciyes University Medical Faculty, Kayseri, Turkey in 1989. His dermatology residency was in Dokuz Eylül University Medical Faculty, Izmir, Turkey between 1992-1997.He is currently working as a professor in the Celal Bayar University Medical Faculty Department of Dermatology, Manisa, Turkiye.He is the member of Dermatovenereology Association of Turkey, Turkish Dermatology Association, Turkish Dermatopathology Association, Turkish Skin and Venereologic Diseases Association, International Society of Dermatology (ISD), European Academy of Dermatology and Venereology (EADV), American Academy of Dermatology (AAD) (Since 2001). Moreover, I am also a board member in International Dermoscopy Society (IDS).
Abstract:
Hair loss is the most common hair problem and a prompt diagnosis of the type of alopecia may sometimes be extremely challenging. Methods commonly used to investigate may be invasive (biopsy), semi invasive (trichogram) or non-invasive (hair count, weighing shed hair and pull test). 'Trichoscopy' represents a valuable, noninvasive technique for the evaluation of patients with hair loss. It allows for magnified visualization of the hair and scalp skin, and may be performed with a manual dermoscope or a videodermoscope. The usual working magnifications are 20-fold to 70-fold. Although the hand-held dermoscope with 10-fold magnification may give easy and quick evaluation of hair, it does not precisely measure or document. Trichoscopic observations can be broadly grouped as hair signs, vascular patterns, pigment patterns and interfollicular patterns. In this presentation, we will briefly describe the trichoscopic findings in the common categories of cicatricial and non-cicatricial alopecias such as androgenetic alopecia, alopecia areata, telogen effluvium, tinea capitis, trichotillomania, lichen planopilaris, discoid lupus erythematosus and hair shaft disorders. This method is simple, quick and easy to perform, reduces the need for scalp biopsy, is well accepted by patients, and is useful for monitoring treatment and follow-up. It represents a valuable link between clinical and histologic diagnosis. New data show that trichoscopy may easily replace light microscopic evaluation of pulled hairs in genetic hair shaft abnormalities.
Session Introduction
Sufiyan M K
Kidzsmile Dental Lounge, Kuwait
Title: Treatments and trends in cosmetic dentistry
Biography:
Dr Sufiyan M K has compleated his bachelor of Dental Surgery in 2011 and Postgraduation in 2015 from Rajiv Gandhi University of Health Sciences, Bengaluru, India. He also has a Fellowship in General Education from Manipal University, India. He has special interest in Dental Cosmetology and Dental Implants. Currently he is working as Prosthodontist and Implantologist in Kidzsmile Dental Lounge Dental Clinic, Kuwait. He has many publications in reputed National and International Journals. He is also in Editorial Board and Reviewer of various journals.
Abstract:
While traditional dentistry focuses on oral hygiene and preventing, diagnosing and treating oral disease, cosmetic dentistry focuses on improving the appearance of the teeth, mouth and smile. In other words restorative, general and/or family dental practices address dental problems that require necessary treatment, whereas cosmetic dentistry provides elective – or desired – treatments or services. Technological advancements in natural-looking, tooth-colored dental materials make today’s cosmetic dental treatments more durable and predictable than in years past. Additionally, dentists are now using more conservative techniques to preserve as much of your natural tooth structure as possible, depending upon specific clinical situation.
Increased interest in cosmetic dentistry continues to spark profound interest in procedures such as laser whitening, computerized smile analysis and straightening.This makes procedures such as smile makeovers more comfortable and convenient for patients, as well as helps to reduce recovery time.
Biography:
Dr. Pamela Benito completed her DDS at Madrid University in 2006 and postgraduate studies from New York University College of Dentistry in 2008.
She then moved to the UK, practising cosmetic dentistry before progressing her career by training in the field of Facial Aesthetics.At the prestigious Royal College of Surgeons, she trained under leading facial aesthetic experts in all aspects of medical aesthetics.
Abstract:
The lips and the perioral soft tissues play a key role in facial attractiveness. The correct soft-hard tissue balance is important for achieving and maintaining a pleasing aesthetic appearance and function.The perioral region is considered one of the most difficult areas to treat as it is the most dynamic.A safe and effective cosmetic practice relies on a thorough knowledge and detailed understanding of facial anatomy. When assessing a patient for perioral rejuvenation, it is essential that the practitioner understands the perioral anatomy so that high-risk areas may be identified and precautions are taken to prevent serious adverse events from occurring.
Rejuvenation of the perioral complex can be very challenging because of the many factors that affect the appearance of this area. To create a more youthful, natural-looking form, the physician endeavours to reverse some of the changes that occur due to ageing. Environmental issues must also be addressed, such as smoking, diet, sun damage, and poor dental health.Ageing of the perioral region seems to be amongst the main reasons people seek surgical or nonsurgical aesthetic treatments. Understanding the components of facial ageing will result in a better understanding of the patient’s individual needs and therefore better-tailored treatment plans.When discussing ideal aesthetics and treatment planning for patients, it is important to recognise the differences in races, genders, cultures and aesthetic ideas.