Scientific Program

Conference Series Ltd invites all the participants across the globe to attend Asia-Pacific Dermatology and Cosmetology Conference Tokyo, Japan.

Day 2 :

Keynote Forum

Evangeline B. Handog

Chair, Department of Dermatology Asian Hospital and Medical Center Philippines

Keynote: Glutathione as a Skin Lightening Agent: Hot Issues on Safety and Efficacy

Time : 09:00 AM

Conference Series Dermatology Meetings 2018 International Conference Keynote Speaker Evangeline B. Handog photo

Dr. Evangeline B. Handog, FPDS, the first woman president of the International Society of Dermatology, is the chair of the Department of Dermatology of Asian Hospital and Medical Center in Alabang, Muntinlupa City. She is a volunteer consultant at the Research Institute for Tropical Medicine where she heads the Cosmetic Dermatology unit. Her interest in pigmentary conditions, particularly melasma and vitiligo is evident in her researches and recently launched book, Melasma and Vitiligo in Brown Skin (Springer). Her passion to teach young residents and help them obtain more knowledge with international mentors was clear as she is the founding chair of the Mentorship Program of the International Society of Dermatology.


Nowadays, skin lightening merchandise is obtainable in the form of creams, pills, soaps or lotions. Sad to note that most are experience based and not evidence based.

Mechanisms to achieve skin lightening include tyrosinase, peroxide inhibition, scavenging of reactive oxygen species and the use of agents against melanogenic inflammatory response. However, the mainstay of skin lightening is of course the regular use of sunscreens.

Glutathione is an ubiquitous compound containing a biologically active sulfhydryl (SH) group found in our bodies. Fruits and vegetables are good dietary sources of glutathione.

Glutathione as a master antioxidant,  helps promote skin whitening. Acting as a primary anti-aging factor, it promotes a longer and healthier life, protects us from harmful free radical damage, supports the immune function, acts as a gate keeper for lungs and gut, detoxifies the body of noxious chemicals, helps to protect against alcohol,  tobacco damage and abuse. It can regenerate spent vitamins C & E in the body.

Until recently, the mechanism of action of Glutathione as a skin whitening agent was unknown.

  1. direct inactivation of the enzyme tyrosinase by binding with the copper-containing active site of the enzyme
  2. mediating the switch mechanism from eumelanin to phaeomelanin production
  3. quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin Formation
  4. modulation of depigmenting  abilities of melanocytotoxic agents. These concepts supported by the various experimental evidence presented form basis for future research in the use of glutathione in the treatment of pigmentary disorders.

Hot issues on IV Glutathione, push or drip, topical route will be dispelled.

Handog EB, Datuin MSL, Singzon IA, did an open-label, single-arm trial of 30 Filipino females (Fitzpatrick skin types IV or V) receiving a glutathione-containing lozenge daily for eight weeks. The authors found a significant decrease in melanin indices from baseline to end point. No serious adverse events, and laboratory examination findings remained normal.

Session Introduction

Sufiyan M K

Kidzsmile Dental Lounge, Kuwait

Title: Treatments and trends in cosmetic dentistry

Dr Sufiyan M K has compleated his bachelor of Dental Surgery in 2011 and Postgraduation in 2015 from Rajiv Gandhi University of Health Sciences, Bengaluru, India. He also has a Fellowship in General Education from Manipal University, India. He has special interest in Dental Cosmetology and Dental Implants. Currently he is working as Prosthodontist and Implantologist in Kidzsmile Dental Lounge Dental Clinic, Kuwait. He has many publications in reputed National and International Journals. He is also in Editorial Board and Reviewer of various journals.


While traditional dentistry focuses on oral hygiene and preventing, diagnosing and treating oral disease, cosmetic dentistry focuses on improving the appearance of the teeth, mouth and smile. In other words restorative, general and/or family dental practices address dental problems that require necessary treatment, whereas cosmetic dentistry provides elective – or desired – treatments or services. Technological advancements in natural-looking, tooth-colored dental materials make today’s cosmetic dental treatments more durable and predictable than in years past. Additionally, dentists are now using more conservative techniques to preserve as much of your natural tooth structure as possible, depending upon specific clinical situation.

Increased interest in cosmetic dentistry continues to spark profound interest in procedures such as laser whitening, computerized smile analysis and straightening.This makes procedures such as smile makeovers more comfortable and convenient for patients, as well as helps to reduce recovery time.


Dr. Pamela Benito completed her DDS at Madrid University in 2006 and postgraduate studies from New York University College of Dentistry in 2008.
She then moved to the UK, practising cosmetic dentistry before progressing her career by training in the field of Facial Aesthetics.At the prestigious Royal College of Surgeons, she trained under leading facial aesthetic experts in all aspects of medical aesthetics.


The lips and the perioral soft tissues play a key role in facial attractiveness. The correct soft-hard tissue balance is important for achieving and maintaining a pleasing aesthetic appearance and function.The perioral region is considered one of the most difficult areas to treat as it is the most dynamic.A safe and effective cosmetic practice relies on a thorough knowledge and detailed understanding of facial anatomy. When assessing a patient for perioral rejuvenation, it is essential that the practitioner understands the perioral anatomy so that high-risk areas may be identified and precautions are taken to prevent serious adverse events from occurring.
Rejuvenation of the perioral complex can be very challenging because of the many factors that affect the appearance of this area. To create a more youthful, natural-looking form, the physician endeavours to reverse some of the changes that occur due to ageing. Environmental issues must also be addressed, such as smoking, diet, sun damage, and poor dental health.Ageing of the perioral region seems to be amongst the main reasons people seek surgical or nonsurgical aesthetic treatments. Understanding the components of facial ageing will result in a better understanding of the patient’s individual needs and therefore better-tailored treatment plans.When discussing ideal aesthetics and treatment planning for patients, it is important to recognise the differences in races, genders, cultures and aesthetic ideas.